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The enzyme '''UDP-glucose 4-epimerase''' (), also known as '''UDP-galactose 4-epimerase''' or '''GALE''', is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity. Additionally, human and some bacterial GALE isoforms reversibly catalyze the formation of UDP-''N''-acetylgalactosamine (UDP-GalNAc) from UDP-''N''-acetylglucosamine (UDP-GlcNAc) in the presence of NAD+, an initial step in glycoprotein or glycolipid synthesis.
Width| caption = ''H. sapiens'' UDP-glucose 4-epimerase homodimer bound to NADH and UDP-glucose. Domains: N-terminal and C-terminal.
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Physics 12
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genealogy 10
Missions 9
Philosophical Transactions of the Royal Society 8
Proceedings of the Royal Society of London 8
Geometry, Analytic 7
mission life 7
Baptism 6
Gales family 6
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Manuscripts 6
Manuscripts -- Bibliography 6
Manuscripts -- England Cambridge 6
Book auctions 5
Catalogues de ventes 5
Korea -- Social life and customs 5
Law reports, digests, etc 5
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Stukeley family. [from old catalog] 5
mission 5
transfers 5
Bible 4
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Infant baptism 4
Live at 35 4
Puritans 4
Rossetti, Dante Gabriel, 1828-1882 4
korea 4
Chicago (Ill.) -- History 3
Compagnie de la Baie d'Hudson 3
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English language 3
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Hudson's Bay Company 3
North West Company 3
Seals (Numismatics) 3
Self-realization 3
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Single women 3
Stukeley family 3
Trigonometry 3
White Christmas 3
bub_upload 3
podcast 3
teaching in korea 3
Alex Gale 2
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American loyalists 2
Bees 2
Black Hawk War, 1832 2
Books 2
Books and reading 2
Bryan, William Jennings, 1860-1925 2
Chemins de fer 2
Clothing and dress 2
Columbia Hall (Hotel : Lebanon Springs, N.Y.) 2
Conduct of life 2
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Ecuador 2
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GALE 2
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Great Britain -- Antiquities 2
Grindcore 2
Indians of North America 2
Lemieux, Gale & Cie 2
Lincoln, Abraham, 1809-1865 2
Livres 2
Macapa 2
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Mechanical engineering 2
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Missions -- Korea 2
Mound-builders 2
Northwest, Old -- History 2
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Pewter 2
Pilgrims (New Plymouth Colony) 2
Pornogrind 2
Proctor, Mortimer Robinson, 1889- 2
Proctor, Redfield, 1831-1908 2
Railroads 2
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United States -- History Civil War, 1861-1865 2
World War, 1914-1918 2
audiobook 2
edr 2
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getting robbed! 2
investigators 2
librivox 2
missionary work 2
museo lázaro galdiano 2
new companion 2
teaching 2
testimony 2
transfer 2
1907 1
1950s popular singer 1
19th birthday! 1
2015 1
ABORTED MISSIONS 1
AIRFOILS - WEDGE - DOUBLE - CHAR & MOMENTS 1
APOLLO PROJECT 1
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Abolitionists 1
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Antislavery movements 1
Argonne National Laboratory 1
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Audio Art 1
Austin 1
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Book collectors -- California Interviews 1
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Brown, Hannah, -1836 1
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